<p>This article deals with the effective beneficiation of sulfide copper ores. <br /> We used the method of creating micro- and nano-sized bubbles in the aqueous <br /> mixture. This method improves the quality of the separation of fine-grained <br /> minerals and helps to reduce the consumption of chemical reagents. In research, <br /> the effects of micro-nanobubbles and collectors (chemical reagents) formed as <br /> a result of the release of gas contained in the bottle through pressure reduction <br /> (depressurization) were studied. According to microflotation experiments, the pre-<br /> deaeration process significantly improves chalcopyrite separation. Additionally, <br /> when micro-nanobubbles form, the collector adheres to the surface of these bubbles <br /> rather than the minerals. This procedure facilitates the aggregation of small <br /> chalcopyrite particles, increasing the probability that they will stick to large bubbles <br /> during the flotation process. n top of that, the sodium diethyl dithiocarbamate <br /> collector stays strongly attached to the chalcopyrite surface even when the pressure <br /> is lowered. Thus, micro-nanobubbles have a positive effect on the flotation of <br /> small chalcopyrite particles, even if the amount of the collector is reduced. This <br /> study helps us better understand the importance of micronanobubbles in mineral <br /> beneficiation processes.</p>