<p>Salt stress enhances the formation of reactive oxygen species in plant tissues associated with damage to the structure of cell macromolecules, leading to disruption of cellular metabolism. The use of drugs of natural origin DAG-1 and DAG-2 can be effective in adapting cotton to the effects of salts. The activity of the pro- / antioxidant system in 7-day-old cotton seedlings, seeds of which were treated with DAG-1 and DAG-2 drugs and germinated in various concentrations of NaCl solution (100 mM, 200 mM, 300 mM) has been studied. Salinity resistance is manifested in cotton varieties treated with natural drugs DAG-1 and DAG-2, in which a high activity of the key enzyme of antioxidant system - superoxide dismutase, low content of final product of lipid peroxidation – malondialdehyde and the accumulation of free proline amino acid with osmoprotective property have been identified.</p>