Journal of Science and Innovative Development ISSN 2181-4317

SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF A NOVEL SYMMETRICAL N,N’-HEXAMETHYLENE BIS [CYCLOHEXANOILOCARBAMATE] N,N’-BIS [PHENYLTHIOUREA] DERIVATIVE

Xudoyberdiyeva Kamola Fazlidin qizi, Muxiddinov Baxodir Faxriddinovich October 29, 2026 DOI: https://dx.doi.org/10.36522/2181-4317/9-3-2026-2

Abstract

<p>Thiourea derivatives stand out in modern organic chemistry due to&nbsp;their diverse biological activities and coordination properties. This study presents&nbsp;the synthesis and detailed structural characterization of a novel symmetrical bis-thiourea derivative, namely N,N&rsquo;-hexamethylene bis[cyclohexanoylcarbamate]&nbsp;N,N&rsquo;-bis[phenylthiourea]. The nucleophilic addition reaction was carried out via the&nbsp;reaction of the starting material, N,N&rsquo;-hexamethylene bis[cyclohexanoylcarbamate],&nbsp;with phenyl isothiocyanate in DMF in the presence of triethylamine as a catalyst.&nbsp;The optimal reaction conditions were determined, the features of the nucleophilic&nbsp;addition (AN) process were investigated, and a plausible reaction mechanism&nbsp;was proposed. The experimental results indicated that, to obtain the bis-thiourea derivative in high yield (68 %), the reaction should be conducted at&nbsp;30 &deg;C for 6 h. The molecular structure was comprehensively confirmed using FT-IR and NMR spectroscopy. FT-IR spectroscopic analysis revealed characteristic&nbsp;stretching vibrations of thioamide groups in the region of 1619&ndash;1573 cm⁻&sup1;, while&nbsp;the corresponding deformation vibration band was identified at 1253 cm⁻&sup1;.&nbsp;<br /> Furthermore, &sup1;&sup3;C NMR spectroscopic data unequivocally confirmed the presence&nbsp;of the thiocarbonyl carbon at 179.24 ppm, while &sup1;H NMR clearly demonstrated the&nbsp;presence of the NH proton of the aryl-substituted group at 9.35 ppm. The presence&nbsp;of a long aliphatic hexamethylene chain and lipophilic cyclohexanoyl groups within&nbsp;the molecule makes this compound a promising precursor for the development of&nbsp;coordination complexes and biologically active substances.</p>

Cite this article
Xudoyberdiyeva Kamola Fazlidin qizi, Muxiddinov Baxodir Faxriddinovich (2026). SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF A NOVEL SYMMETRICAL N,N’-HEXAMETHYLENE BIS [CYCLOHEXANOILOCARBAMATE] N,N’-BIS [PHENYLTHIOUREA] DERIVATIVE. Journal of Science and Innovative Development. https://doi.org/https://dx.doi.org/10.36522/2181-4317/9-3-2026-2