<p>Created compositions of wound coatings based on collagen (WCC) isolated om ca le tendons with additives of biologically active compounds, such as alkaloids om plants of the genus Convolvulus (convolvin, convolamin, llalbin), and avonoids isolated om the buds of the Saphora japonica plant (quercetin, rutin) . It is established that alkaloids and avonoid rutin have antimicrobial activity. On the physic-chemical properties of the WCC with alkaloids were rejected, due to low adhesion and strength. WCC with quercetin (QU-WCC), llalbin (F-WCC) and rutin (RU-WCC) showed a good e ect in the treatment of purulent wounds of the skin. In experimental models of purulent wounds, QU-WCC reduced the time of epithelialization of purulent wounds by 11.1-12.2 days (fully wounds were epithelized by 17.2 ± 0.1 days), RU-WCC reduced the terms of epithelialization of purulent wounds by 8.4 – 9.2 days (fully wounds were epithelized for 20.1 ± 0.2 days), F-WCC reduced the time of epithelialization of purulent wounds by 11,5-12,4 days (fully wounds were epithelized by 16,9±0,2 days) compared with control wounds with no treatment (completely wounds were epithelized for 28.9 ± 0.6 days). e e ect is due to the antioxidant properties of quercetin and rutin, as well as the antimicrobial activity of rutin and the natural, hypoallergenic and histocompatible collagen matrix. e resulting RP compositions are non-toxic (hazard class 5), do not cause local irritation, are histocompatible, hypoallergenic and correspond to the properties speci ed for wound dressings.</p>