<p>Of all the infectious diseases that exist in the silkworm, pebrine is especially dangerous. Its particular danger lies in the transovarian transmission of the pathogen. The disease affects all phases of the silkworm development and is transmitted to the next generation through eggs (grena). The aim of this research is to study the impacts combinations of pharmaceutical preparations may have on the silkworm eggs’ house that has been slightly infected with the pebrine. As a result of the implemented research, the infection rates in the test cases were expressed in 8,0-14,7 %. Treatment of grena with normal water containing no chemical factor, resulted in 27,6% of contamination in the test case. The best effective result is determined in the options of Metronidazole 500 mg + Ciprofloxacin 500 mg - contamination 8,0 % and Metronidazole 500 mg + anolyte - with 9.5% of </p> <p> </p>